Our research focuses on transcriptional regulation mechanisms mediated by the transcription factor NRF2 (Nuclear factor erythroid 2–related factor 2), a key regulator of the cellular response to oxidative stress and changes in the tissue microenvironment. We aim to understand the molecular mechanisms underlying NRF2 activation, which contribute to maintaining redox homeostasis and modulating cellular responses in complex pathophysiological contexts, such as solid tumors and neovascular retinopathies. Using molecular and transcriptomic approaches, we investigate the environmental signals that influence NRF2 activity and the gene networks it regulates, with the goal of identifying new therapeutic targets and intervention strategies for these diseases.
Researchers involved:
- Federico Marchini (PhD)
- Aurora Iacopini (PhD)