OVERVIEW
The emergence of mycobacterial strains that are extremely resistant or totally resistant to currently available antitubercular drugs has driven the search for new anti-mycobacterial agents. In this context, the research group is active in the study of pyrrolic compounds capable of blocking the MmpL3 protein, which is essential for mycobacterial survival. More recently, polyaza compounds with antitubercular activity have been identified, acting through inhibition of the catalytic activity of the mycobacterial carbonic anhydrase CanB.