Studies on inhibition and regulation of human enzymes and proteins involved in cancer and neurodegenerative disorders

These studies aim to provide the structural basis for the development of innovative drugs to fight different pathologies. The understanding of protein function and the protein-protein interactions that are involved in metabolic pathways allows to conceive innovative molecules able to regulate such pathways and to contrast the progression of such pathologies. The systems studied are human thymidylate sinthase, human PIM kinases, human QPCT, peptides involved in Alzheimer disease.


Researchers involved

  • Daniela Valensin
  • Gianni Valensin


  • Cecilia Pozzi - Assegnista 
  • Flavio di Pisa - Dottorando/Assegnista
  • Lucia dello Iacono - Dottorando



  • Maria Paola Costi (Università di Modena e Reggio Emilia)
  • Stefania Ferrari (Università di Modena e Reggio Emilia)
  • Rebecca Wade (HITS GmbH, Heidelberg)