Concluded international research projects

Bioprocessing for Sustainable production of COLoured textiles - BISCOL

Development of a new dyeing process based on the ecological optimisation of the overall dyeing process cycle, for European textile SMEs.

The objective of the European project BISCOL is to propose a new dyeing process as global alternative for the bioconversion of raw materials into competitive eco-viable final products through the optimization of:

-       textile pre-treatments, aiming to increase dyeability of textiles versus bio-dyes:

-       synthesis of bio-dyes, using new safe and environmental friendly routes by enzymatic processes

-       synthesis of new auxiliaries at lower environmental impact

-       optimisation of dyeing process, reducing energy demand (e.g. lowering temperature and time of treatments).

All steps will be assisted by Life Cycle Assessment, to embed environmental constrains in each step of the process.

Partners: Next Technology Tecnotessile (Italy), Achimo (Italy), Lanificio Luigi Ricceri (Italy),Wetlands Incubator (Belgium), SETAS Chemicals (Turkey)


CIP Eco-Innovation european project Eco/09/256112 BISCOL


Project Coordinator

Understanding the molecular science of aromatic waste degrading enzymes

This proposal brings together two groups in the UK and Italy. Working together, new and significant insights into the nature of the oxygenase enzymes will be gained. 

The majority of microorganisms involved are aerobic, and therefore grow in the presence of molecular oxygen. These organisms are able to directly attack the relatively ‘inert’ aromatic or aliphatic carbon centres in pollutant compounds, and activate these structures to further biological or chemical attack.  The enzyme catalysts employed in this process are a group of enzymes known as the oxygenases. By studying the oxygenase enzymes at the molecular level we will ultimately aim to address the limiting factors that prevent the full exploitation of oxygenase-utilising organisms, and understand the main processes involved in the cycling of organic pollutants in the environment.

British-Italian Partnership Programme

Italian Coordinator

Financialization, economy, society and sustainable development – FESSUD

The Project aims to evaluate financial instruments and policies in pursuit of sustainability in the field of climate change assessing to what extent fuel prices can promote transition towards a more efficient energy regime. As an higher efficiency lowers the price of energy and boosts energy consumption, often the phenomenon called Rebound Effect arises counteracting the efficiency actions. The RE within the scope of decoupling economic growth and energy growth in the light of the triggering role of oil prices.

7° Framework Programme

Partners: Dept of Political Economy, Leeds University and other 23 partners

Researchers involved




Remote sensing based monitoring of carbon dynamics (CarbMonit)

Leading scientists in China and Italy are examining key mechanisms in carbon sequestration and release from aquatic ecosystems by developing new technologies for the monitoring and modelling of these dynamics.

Coastal and inland waters play a vital role in carbon sequestration and exchange. Because climate change will modify catchment sources, local hydrology and degradation processes, significant modifications on carbon sequestration and emission to the atmosphere are expected in the coming decades.Leading research institutions in China and Italy are collaborating to examine carbon sequestration and release from aquatic ecosystems and develop new technologies to improve our analysis and monitoring capacities. Scientists are developing algorithms for the analysis of carbon dynamics in optically complex aquatic ecosystems and models to examine temporal and spatial variability of carbon related bio-optical properties of major aquatic ecosystems in Europe and Asia.


European Space Agency – Chinese NRSCC

Partners: Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences

Researchers involved

East African Great Lakes Observatory (EAGLO)

The EAGLO scientific consortium is creating regionally based instruments for the sustainable management of large lake ecosystems in East Africa.

The African Great Lakes are among the world’s most important aquatic ecosystems being heavily utilised by their bordering countries for transportation, water supply, fisheries, waste disposal, recreation and tourism. The livelihoods of more than 40 million people are largely dependent on the services that these lakes provide, but evidence shows that climate change and regional environment drivers are compromising ecosystem functioning. The international team of scientists is developing regionally coherent approaches for the monitoring and management of large lakes in Eastern Africa. Through a close collaboration, project scientists have developed innovative methodologies and models to examine the impact of future scenarios of climate change and evolving socio-economic conditions on ecosystem services and lake dynamics.

Partners: College of Biological and Physical Sciences (University of Nairobi, Kenya), University of Leicester (UK), Deltares (NL), Makerere University (Uganda), University of Namur (BE), Tanzanian Fisheries Research Institute (TZ), ISP Bukavu (CO), Institut National Polytechnique de Toulouse (FR), University of Cadiz (ES), University of Bahir Dar (ET), Lake Tanganyika Authority, Malawi Polytechnic (MW)

Researchers involved

New medicines for trypanosomatidic infections

The infectious diseases burden imposed by the parasites of Trypanosomatidae family represents a huge problem on people’s lives in countries where diseases are endemic. Problems associated with existing drugs include inefficient delivery, insufficient efficacy, excessive toxicity and increasing resistance. New drugs are urgently needed. The project uses a highly interdisciplinary approach to optimize pteridine, benzothiazoleand miltefosine derivatives as well as natural products against Trypanosomatids.


Health FP7 2013-2016 NMTrypl

Partners: Università di Modena e Reggio Emilia, European Screening Port –Hamburg, Instituto de Biologia Molecular e Celular – Lisbona, National Center for Research – Karthoum Sudan, Hypha Discovery Uxbridge UK, National Hellenic Research Foundation– Atene, Grecia , Alunda Universidad Complutense – Madrid, Spain

Project Coordinator

Development of novel antiviral drugs against Influenza

The FLUCURE project amis at developing innovative, first-in-class therapeutics against influenza by targeting the viral ribonucleoprotein complez, which is replication core of the virion and a major contributor to viral virulence.


FP7 - HEALTH.2010.2.3.3.-4 HEALTH

Partners: VIRONOVA AB (Sweden), BEACTICA AB (Sweden), Pike Pharma GMBH (Switzerland), Universitaetsklinikum Freiburg (Germany), Insitute of Organic Chemistry with Centre of Phytochemistry - Bulgariana Academy of Sciences (Bulgaria), Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoed en Patientenzorg (Netherlands), Vilniaus Universitetas (Lithuania), Pharmacelsus GmbH (Germany)

Researcher involved:

First principles study of photoinduced non -adiabatic dynamics in DNA repair by photolyases - PINADBio

New approach for the mechanistic investigation of the photolyase repair.


FP7 - Support for training and career development of researchers (Marie Curie) - International Outgoing Fellowships (IOF)


Researcher involved:

  • Dr. Loic Joubert-Doriol

Funding: EU FP7


The Royal Liverpool and Broadgreen University Hospital, The University of Liverpool; National Institute of Rheumatic Diseases; Assistance Publique Hopitaux de Paris; PSR Group BV; Cudos B.V.; Nordic Bioscience Compound Development; The AKU Society; Swedish Orphan Biovitrum AB (Publ); Institute of Molecular Physiology and Genetics; Association pour la lutte contre l’Alcaptonurie; Institut Necker

Rsearcher involved

Targeting the HIV-1 Nucleocapsid Protein to fight Antiretroviral Drug Resistance – THINPAD


- discover and develop novel anti-HIV agents targeting the HIV nucleocapsid protein(NC), which is one of the most conserved sequence within HIV strains and is higly required for HIV replication. being therefore a primary target to overcome antiretroviral drug-resistance.



Consorci Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Universit de Strasbourg (UNISTRA), IRBM Science Park (IRBM), ViroStatics srl.


Poject Leader

Photochemistry at the Ocean's Surface: Effects and Interactions of Dissolved Organic Matter with Microplastics — POSEIDOMM

Funding: HORIZON 2020 MSCA-IF-2015-EF - Marie Sklodowska-Curie Individual Fellowships (IF-EF)



- provide a chemical and biological characterization of the microplastic-biofilm aggregates in the SML, to quantify the photochemical cycling of such aggregates and to identify the implications of this cycling on gas exchange and on the microbial carbon cycle. This will be achieved through a trans-disciplinary approach combining innovative spectroscopic and biological analyses to study the SML in controlled microcosms and in-situ mesocosm studies.


UNISI Leader


Funding: FP7-HEALTH.2013.2.3.4-2

Objective: development of 1-2 candidate drugs for non human primate evaluation (depending on the compound class) including pharmacokinetic (PK) and pharmacodynamic (PD) evaluation on BALB/c mice, hamsters and testing on dogs.


UNISI leader:

Multi-target inhibitors against metalloproteases for developing effective anti-Mycobacterium drugs Funding: British society for Antimicrobial Chemotherapy -

Grant won by Dr. Simone Brogi



- discovery and design of multi-target agents against three different metallo enzyme necessary for Mycobacterium tuberculosis (MTB) growth and infection already established as virulence factors and attractive drug targets


UNISI leader:

Targeted small-molecule stabilisation of protein-protein interactions – TASPPI

Funding: HORIZON2020 - MSCA-ITN-2015

Partners: Technische Universiteie Eindhoven, University of Leeds, Univerzita Karlova V Praze, University of Dundee, Centre National de la Recherche scientifique, Lead Discovery Center GmbH, Astrazeneca AB, Taros Chemicals GmbH & Co. KG, UCB Biopharma sprl

UNISI leader: