Direct inhibition of heat shock protein-90 and its indirect inhibition via histone deacetylase-6 (HDAC6) inhibition have recently been identified as a novel therapeutic opportunity for neurodegenerative disorders. Inhibition of both targets has, as a result, the production of neuroprotective chaperons such as Hsp70 and Hsp40. The development of Hsp90 inhibitors and selective HDAC6 inhibitors represents the object of this research activity.
- Giuseppe Campiani
- Brogi Simone - PostDoc
- Cavella Caterina - Ph.D. student