Research topics
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Pharmacy
Antitumor compounds
1] Development of compounds endowed with a pyrrolobenzoxazepine structure
2] Development of Bcl-2 molecular switchers
Design and synthesis of arylpiperazine derivatives related to quipazine and characterization of their interaction with 5-HT3
Design, synthesis, and structural characterization of new polymeric substances and their evaluation in controlled drug release
Development of antalgic agents
Development of: 1) selective FAAH and MAGL inhibitors, 2) Adenosine Kinase inhibitors, 3) GluK1 agonists and antagonists
Development of anti-parasitic and antiviral agents
1] Development of novel antimalarials
2] Development of antiviral and anti-infective agents
Development of compounds acting on CNS
1] Drugs and diagnostics for Alzheimer disease
2] Modulation of dopaminergic and serotoninergic systems
Drug Design, Synthesis and Biological Evaluation of New Neuroprotective Agents Potentially Useful in Brain Diseases
Hsp90, HDAC6 and neurodegeneration
This research activity focuses on the development of inhibitors of Hsp90 and HDAc6 for the therapy of neurodegenerative disorders
Organic synthesis of molecules having an aromatic and/or an heterocyclic structure with potential pharmacological activity
Set up and validation of analytical methods for quali-quantitative determination of drugs and their metabolites
Synthesis and Pharmacological Characterization of Positive Allosteric Modulators of the GABAB Receptor
Synthesis and pharmacological characterization of metabolically stable, orally effective, PAMs of the GABAB receptor
Synthesis and pharmacological evaluation of novel, selective CB2 ligands
The research on CB receptors aims at the identification of CB2 agonists as potential pharmacological tools in a number of pathological states
Synthesis of new cycloogenase-2 (COX-2) inhibitors
Synthesis of new ligands for the central (CBR) and peripheral benzodiazepine receptor (PBR–TSPO)