The research theme is developed jointly with a pharmaceutical company in order to develop clinical candidates in the field of non-steroidal anti-inflammatory drugs (NSAID). Significant results have been obtained with the discovery of very potent and selective diarylpyrrole inhibitors, which have evolved in hybrid molecules potentially able to release nitric oxide (NO) and contemporary to inhibit cycloogenase-2 (COX-2) in order to obtain NSAIDs with reduced gastrointestinal and cardiovascular side effects.
Researchers involved
- Angela di Capua - Ph. D. student