Post-doctoral and technician positions at Laboratory of Stem Cell and Neurogenesis, Division of Neuroscience, Ospedale San Raffaele, Milan-Italy
Two positions are immediately available in the Laboratory of “Stem Cells and Neurogenesis” at Ospedale San Raffaele on the project “Exploring the symptomatic reversibility of Dravet syndrome in murine and human models”, funded by Fondazione Telethon and Associazione Gruppo Famiglie Dravet.
We are looking for:
- a post-doctoral researcher; the ideal candidate is a highly motivated PhD scientist who wishes to advance in his/her academic training and consolidate the research experience in neuroscience. A specific background in cellular and molecular biology and experience with animal model manipulation are required.
- a research technician with experience in murine models, animal handling and care. Additional experience in mouse behavior will be considered as a plus.
The post holders will join a team working on Dravet syndrome, a devastating infantile encephalopathy with pharmaco-resistant epileptic seizures and behavioral alterations caused by loss of sodium channel activity. The project aims at testing the reversibility of the syndrome with both genetic and pharmacological approaches.
Salary
The positions will be funded for one year and renewable up to 3 years and salary will be determined according to the candidate experience.
Selection process
Please send your applications including a summary of research interest, Curriculum vitae, and at least two contacts for reference by email to: colasante.gaia@hsr.it
Gaia Colasante
Stem Cell and Neurogenesis Unit
Division of Neuroscience
Ospedale San Raffaele, Milan-Italy
Computational Scientist
Post-doctoral fellowship
The Cancer Epigenetics Lab https://www.crick.ac.uk/Paola-scaffidi is looking for an enthusiastic postdoctoral fellow interested in studying how
disruption of epigenetic control and transcriptional deregulationcontribute to cancer development. The successful candidate will be
expected to develop a project addressing important biological questionsrelated to: robustness and plasticity of epigenetic regulation,
transcriptional stochasticity, phenotypic intratumour heterogeneity, orany other interesting topic that fits into the general interests of the lab.
The appointed postdoctoral fellow will both work side-by-side withexperimentalists and mine publically available datasets.
We are based at the Francis Crick Institute in central London https://www.crick.ac.uk and benefit fromcore-funding by Cancer Research UK, the UK Medical Research Council, and the Wellcome Trust.
Some recent studies:
Torres et al, Science 2016 – epigenetic basis of intratumour heterogeneity Chakrabarti et al, Molecular Cell 2019 – CRISPR mechanisms Mourikis et al, Nature Communications 2019 – machine learning to identify cancer drivers
The position:
• 4-year fellowship, with a possible extension for up to 6 years in total
• Access to state-of-the-art facilities and Science Technology Platforms https://www.crick.ac.uk/research/platforms-and-facilities, and collaborativeand multidisciplinary research culture
• Competitive salary, based on experience, with benefits
Qualifications:
• Strong quantitative research background with a PhD in areas such ascomputer science, bioinformatics, mathematics, physics or related disciplines
• Demonstrated ability to perform high-quality research, and capacity toformulate hypotheses, test them and follow through
• Experience with single cell transcriptomics and/or transcriptional regulatorynetworks and/or systems biology is highly preferred
• Strong and evident motivation, creativity, excellent communication skills and genuine enthusiasm for science
Further information on the Crick postdoctoral programme can be found at:
https://www.crick.ac.uk/careers-and-study/postdocs/postdoc-programme and
https://www.crick.ac.uk/careers-and-study/postdocs/postdoc-community
If you are interested in joining the Scaffidi Lab, please send a cover letter and a CV to Paola.Scaffidi@crick.ac.uk
A Staff Scientist position is available in the DNA replication and genome stability laboratory lead by Francesca M. Pisani at the Istituto di Biochimica e Biologia Cellulare (IBBC, ex IBP), CNR, Via P. Castellino 111, Naples, Italy.
The selected candidate will join a project focused on the analysis of the coupling between DNA replication and sister chromatid cohesion in human cells. Complementary experimental approaches will be used including biochemistry, molecular and cellular biology techniques as well as single-molecule biophysical analyses with correlative optical-tweezers fluorescence microscopy.
The following qualifications, skills and experience are required:
• PhD and Post-Doctoral experience
• Expertise in molecular and cell biology (CRISPR-Cas9, transfection techniques, retroviral/lentiviral infection, cell-cycle/apoptosis analysis, cell-survival and -proliferation assays). Expertise in protein biochemistry will be a plus.
• At least two publications as a first author in peer-reviewed journals
• Excellent written and oral communication skills in English
A 4-year full-time contract (“Ricercatore CNR, III livello, con contratto a tempo determinato”) is offered with a salary of 50,000 Euros/year, starting in February/March 2020.
Candidates are invited to send informal applications (containing CV with a publication list) to Francesca M. Pisani (e-mail: fm.pisani@ibp.cnr.it; mobile: +39- 3396313841).
Two Post-doctoral positions in Vascular Biology (assegno di ricerca) The positions One three-years postdoc and one one-year postdoc positions in Vascular Biology are available at the Department of Biosciences of the University of Milan, in the group of Dr. Alessandro Fantin.
The positions are funded by a competitive salary supported by a private foundation and departmental funds.
Qualification The postdoctoral researchers will be a highly motivated and career-oriented research fellows with a high level of independence and a PhD degree in molecular, cellular or developmental biology, or equivalent. Experience with tissue culture and mouse or zebrafish in vivo handling is essential. Expertise in transcriptomic profiling and mouse surgery will provide a selective advantage.
Candidates possessing excellent analytical, organizational and communication skills in spoken and written English must be able to work independently as well as with interdisciplinary teams. The project The formation of blood vasculature (angiogenesis) is a physiological process during development. However, angiogenesis can be stimulated following injury or during certain diseases, such as solid tumours and neovascular eye diseases. Instead, the formation of new vessel circuits can compensate for the lack of blood flow following ischemia.
The laboratory of Vascular Physiology (https://bioscienzebio.unimi.it/gruppo.php?id=54 ) is interested in understanding how macrophages and myeloid progenitors of the immune system promote angiogenesis during development and in neovascular diseases. Lab webpage: https://bioscienzebio.unimi.it/gruppo.php?id=54. Publications of the lab relevant for this project: Plein et al., Nature 2018; Liyanage et al., Arter Thromb Vasc Biol 2016; Fantin et al., Nature Protocols 2013; Fantin et al., Blood 2010).
The environment The laboratory of Vascular Physiology is part of the Department of Biosciences, which has recently gained the “Department of Excellence” award and financial support by the Italian Ministry of Education, Universities and Research (MIUR). The department is an international environment with a wide expertise, including bioinformatics and cellular, molecular and structural biology, offering an exceptional research environment and access to cutting-edge departmental advanced facilities (https://bioscienzebio.unimi.it/facility.php) and four University Unitech platforms (https://www.unimi.it/en/node/503). Finally, the lab is located in Milan, a cosmopolitan city, which has been ranked number one for quality of life in Italy: https://www.turismo.milano.it/wps/portal/tur/en. Interested candidates should submit their application including CV, a cover letter with description of research interests and the contact information of at least two referees to Alessandro Fantin at alessandro.fantin@unimi.it.
The International Max Planck Research School in Chemical and Molecular Biology (IMPRS-CMB) is looking for talented and motivated PhD candidates of all nationalities with a background in MOLECULAR and CELL BIOLOGY, BIOCHEMISTRY, BIOPHYSICS, APPLIED and THEORETICAL PHYSICS, MEDICINAL CHEMISTRY, CHEMICAL BIOLOGY, STRUCTURAL BIOLOGY, SYSTEMS BIOLOGY and related fields.
Online applications are possible from today. DEADLINE: October 31st, 2019.
For further information and to apply, please visit our webpage https://www.imprs-cmb.mpg.de
The International Max Planck Research School for Molecular Life Sciences (IMPRS-LS) is a PhD program that brings together two renowned Munich based Max Planck Institutes (MPI of Biochemistry and MPI of Neurobiology) as well as two leading German universities, the LMU and TUM, to deliver first class doctoral training for the world‘s most promising young scientists.
Our students enjoy world class research facilities, dedicated training workshops and supervision from faculty members who are leaders in their respective fields. Combined with a focus on early independence in research, our PhD program ensures those aiming for a successful career in science have the very best starting platform.
More than 60 distinguished group leaders actively participate in the PhD program and offer challenging and cutting-edge PhD projects in the following areas:
- Biophysics & Bio-imaging
- Computational & Systems Biology
- Gene Regulation & DNA Biology
- Circuit Neuroscience & Neurodegeneration
- Protein Structure & Protein Folding
- Signalling & Immunology
We invite talented, creative and enthusiastic students with a commitment to basic science to apply before November 15, 2019.
All students accepted to the program will receive a generous PhD fellowship including social benefits and travel support.
Further information and application details are available at: www.imprs-ls.de
